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Dr. Andrew Singson will present, Gamete activation and fertilization in C. elegans
Friday, September 02, 2011
Reproductive success requires that two haploid cells – sperm and egg – unite to form a diploid zygote. After fertilization has occurred, the zygote must begin development. From extensive study, the events required for reproductive success are known in some detail. However, the molecular underpinnings of these events generally remain elusive. My lab has been helping to pioneer the use of C. elegans for addressing the mechanisms of sperm-egg interactions. Many of the genetic and molecular tools developed for C. elegans are not available or are very difficult to utilize in other organisms traditionally used for studying fertilization. The most significant advantage of C. elegans is the ability to isolate and maintain mutants that affect sperm or eggs and no other cells. We have focused our studies on several classes of sterile mutants. These mutants define genes required for sperm activation, sperm function during fertilization, egg function during fertilization and egg activation. I will discuss our current progress based on the study of these genes. Link

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