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Research Seminar: Dr. Joseph Landolph Jr will present, Nickel-induced Global Disruption of Gene Expression Results in Morphological/Neoplastic Transformation of C3H/10T1/2 Mouse Embryo Cells
Monday, September 26, 2011, 12:00pm
(12pm LSB Auditorium) Dr. Joseph Landolph Jr.; Keck School of Medicine, University of Southern California, Department of Comprehensive Cancer Center, Los Angeles, CA

Abstract: Insoluble Ni compounds induced morphological transformation (Tx) of 10T1/2 cells.  130 genes were differently expressed in Ni/MCA-Tx cell lines. Ect-2, calnexin, Wdr1 genes were over-expressed; ect-2 amplified; DRIP/TRAP80 and b-centaurin-2 genes were silenced, in Tx cell lines. Differential expression of these genes caused morphologic Tx of 10T1/2 cells.

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