ADVANCED CELL BIOLOGY//MOLECULAR BIOLOGY OF CELLS
Fall 2009 LECTURE SCHEDULE: 01-146:470 + 16-148:514
Course coordinator: Prof. David Denhardt (Nelson, A301, ;
Faculty: Prof. Ron Hart (rhart@rci.rutgers.edu); Prof. Charles Martin (martin@biology.rutgers.edu);
Prof.Martin Grumet (mgrumet@rci.rutgers.edu); Prof. Beatrice Haimovich (Haimovich@umdnj.edu);
Prof. Gary Brewer (brewerga@umdnj.edu); Prof. Guy Werlen (werlen@biology.rutgers.edu);
Prof. Barth Grant (grant@biology.rutgers.edu); Prof. Yacov Ron (yron@umdnj.edu).
First period (8:40-10:00 AM) Monday and Thursday, Fall semester - SEC 118.
The text is MOLECULAR CELL BIOLOGY by Lodish, Berk, Matsudaira, Kaiser, et al. 6ed, WH Freeman.
Website access: http://lifesci.rutgers.edu/~denhardt/course/AdvCellBiol.2009.htm
(for Dr. Hart’s lectures it is: http://spine.rutgers.edu/cellbio/default.htm).
September 3 - Course overview; review of cell structure and function DTD (Chapters 1, 2) PPT PDF
September 8 (Tues) - Nucleic acid structure and function, RH (4.1 – 4.4)
September 10 - Protein structure and function, CM (3.1-3.5) PDF HMWK
September 14 - DNA replication and repair, RH (4.5 – 4.6)
September 17 – Methods to study and manipulate DNA and proteins RH (5.1 - 5.3)
September 21– Chromatin structure and mobile genetic elements RH (6.1 – 6.3, 6.6)
September 24 - The Cell Cycle, DTD (Chapter 20.1 – 20.7) HMWK PPT PDF
September 28 - Methods to study and manipulate DNA and proteins RH (5.4 - 5.5)
October 1 – Genomics RH (6.5)
October 5 - Exam #1
October 8 - Biomembranes, structure function, CM (Chapter 10, 13.1-13.3,13.6) HMWK PPT PDF
October 12 - Membrane Transport, CM (Chapter 11) HMWK PPT PDF
October 15 - Secretion BG (Chapter 9.1, 14.1-14.4) HMWK PPT PDF KELL UOBF BG1 BG3 BG4
October 19 - Endocytosis BG (Chapter 9.2-9.3, 14.5-14.6) HMWK PPT PDF BG2RAB5 CLATHRIN
October 22 - Transcription, GB (Sections 7.1 – 7.8, 21.3, pp. 969-977) HMWK PPT PDF
October 26 - RNA processing I, GB (Sections 8.1 through 8.3 and pp 357-367) PPT PDF
October 29 - RNA processing II, GB (pp.352-353 [“Degradation of mRNA and P Bodies”); section 13.6)
November 2 - Translation, GB (4.3,4,4; pp347-356; Sect 13.1; pp908-910; figs + legends in attached paper) PPT PDF
November 5 - Immunity, YR (Chapter 24) HMWK PPT PDF
November 9 – Exam #2
November 12 - The Cytoskeleton, BH (Chapter 17) HMWK PPT PDF
November 16 - Motor Proteins, BH (Chapter 17-18) PPT PDF
November 19 - Movement and Cell Motility, BH (Chapter 18). PPT PDF
November 23 – Signal Transduction I: (GW) Chapter 15: intro, 15.1, 15.2, 15.3, 15.4, 15.6, 15.7. PPT PDF HMWK
November 30 - Signal Transduction II: (GW) Chapter 16: intro, 16.2, 16.3, 16.4, 16.5, 16.7. PPT PDF
December 3 - Cell Junctions and Cell adhesion MG (Sections 9.5, 19.1, 19.2, 19.5) PPT PDF HMWK
December 7 - Extracellular Matrix/Neural Development MG (Sections 19.3, 19.4, 22.3, 22.5) PPT PDF HMWK1 HMWK2 HMWK3
December 10 - Cancer, DTD (Chapter 25) PPT PDF
Dec 17 - exam #3 146:470 148:514 146:470FinalGrade 148:514Final Grade
The third 80-min exam (#3) will be given on Thursday Dec 17 from 9:00 - 10:20 AM in the Physics Lecture Hall (which is the round building that sits close to Freulinghuysen Road near the SEC Building).
Course evaluation: Please note that the powerpoint slides for each lecture can be accessed by clicking on the highlighted title; homework questions are accessed similarly. There will be three 80-min exams that will count for 80% of the grade. Before each lecture, students will submit to Dr. Denhardt or the lecturer brief answers to questions on the subject of the lecture. The quality of the students’ answers will count for 20% (undergraduates) and 10% (graduate students). The graduate students will be asked to write a 3-5-page paper on a topic of their choice. This paper, worth 10% of the final grade, must be submitted to the professor who will grade it no later than Friday, Dec. 11. The paper may be on any subject covered by any of the lecturers. The format of the paper (e.g. a critical review of a subject or a critique of a paper) must be approved in advance by Dr. Denhardt and the professor who will grade it. A key part of the grade will be evidence of creative thinking, as opposed to simply a rehash of the literature, on the part of the student.
