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Jean Baum
Professor
Rutgers University
Wright-Rieman Labs
Department of Chemistry
Piscataway. NJ 08854
(732) 445-5666
FAX - 5312
baum@rutchem.rutgers.edu |
NMR. protein folding. molecular recognition
Our research involves the development and application of nuclear magnetic
resonance (NMR) spectroscopy to the study of proteins. Methods of high-resolution
NMR in conjunction with computer algorithms are used to examine the dynamics
and three-dimensional structures of proteins in solution.
One area of interest is to use NMR to understand the manner in which a protein
folds from an unstructured state to its final compact globular structure.
The study of the folding intermediates may provide a description of the
pathways by which this important process occurs. A second area of interest
involves protein-protein interactions and molecular recognition in proteins
of medical and biological interest. The emphasis of the research is to develop
novel NMR methods and apply existing techniques to model peptide and protein
systems in order to explore these important problems in biophysical chemistry.
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