Gabriella D'Arcangelo Associate Professor Rutgers University Cell Biology & Neuroscience Nelson Biological Laboratories 604 Allison Road, Room B319 Piscataway. NJ 08854-8082 (732) 445-2839 FAX - 1794 darcangelo@dls.rutgers.edu

Molecular mechanisms of neuronal proliferation, differentiation and migration

My research focuses on understanding basic mechanisms governing brain development using the mouse as a model system. We also seek the opportunity to apply this knowledge towards a better treatment for human neurological disorders. Three major projects are currently pursued in my lab:

1) Function of Reelin in brain development.
2) The phosphatidylinositol pathway in human cortical dysplasia.
3) Role of Dyrk1A in neurogenesis and differentiation.

Selected Publications

D'Arcangelo G. (2009) From human tissue to animal models: Insights into the pathogenesis of cortical dysplasia. Epilepsia. 50 Suppl 9:28-33.

Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G. (2009) Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech. 2(7-8):389-98.

Zhang, G., Assadi, A.H., Roceri, M., Clark, G.D. and D'Arcangelo, G. (2009) Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1. Brain Res 1267: 1-8.

Niu S, Yabut O, D'Arcangelo G. (2008) The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J Neurosci. 28(41):10339-48.

Assadi AH, Zhang G, McNeil R, Clark GD, D'Arcangelo G. (2008) Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice. Neurosci Lett. 439(1):100-5.

Zhang, G., A.H. Assadi, R.S. McNeil, U. Beffert, A. Wynshaw-Boris, J. Herz, G.D. Clark and G. D'Arcangelo (2007) The Pafah1b complex interacts with the Reelin receptor VLDLR. PLoS ONE 2: e252.

Ljungberg, M.C., M.B. Bhattacharjee, Y. Lu, D.L. Armstrong, D. Yoshor, J.W. Swann, M. Sheldon and G. D'Arcangelo (2006) Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol 60: 420-9.

D'Arcangelo, G. (2006) Reelin mouse mutants as models of cortical development disorders. Epilepsy Behav 8: 81-90.

D'Arcangelo, G. (2005) Apoer2: a reelin receptor to remember. Neuron 47: 471-3.

D'Arcangelo, G. (2005) The reeler mouse: anatomy of a mutant. Int Rev Neurobiol 71: 383-417.

Niu, S., A. Renfro, C.C. Quattrocchi, M. Sheldon and G. D'Arcangelo (2004) Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron 41: 71-84.

Assadi, A.H., G. Zhang, U. Beffert, R.S. McNeil, A.L. Renfro, S. Niu, C.C. Quattrocchi, B.A. Antalffy, M. Sheldon, D.D. Armstrong, A. Wynshaw-Boris, J. Herz, G. D'Arcangelo and G.D. Clark (2003) Interaction of reelin signaling and Lis1 in brain development. Nat Genet 35: 270-6.

Deguchi, K., K. Inoue, W.E. Avila, D. Lopez-Terrada, B.A. Antalffy, C.C. Quattrocchi, M. Sheldon, K. Mikoshiba, G. D'Arcangelo and D.L. Armstrong (2003) Reelin and disabled-1 expression in developing and mature human cortical neurons. J Neuropathol Exp Neurol 62: 676-84.

Quattrocchi, C.C., F. Wannenes, A.M. Persico, S.A. Ciafré, G. D'Arcangelo, M.G. Farace and F. Keller (2002) Reelin is a serine protease of the extracellular matrix. J Biol Chem 277: 303-9.