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Pediatric head and neck cancersOur laboratory is interested in the role of bone marrow-derived cells in solid tumor growth and injury repair. MSCs are a multipotent cell type found in the adult bone marrow. These cells home to areas of injury and tumor growth through a vascular route In collaboration with Dr. Debabrata Banerjee’s laboratory at CINJ we have begun to study the signaling mechanisms that lead to mobilization of MSCs from the bone marrow and their homing to tumors and sites of injury. We are also investigating the differentiation of MSCs that occurs during tumor growth and injury repair as well as the effect of MSCs on other cellular components of the microenvironment such as macrophages. Selected PublicationsMishra PJ, Mishra PJ, Glod JW, Banerjee D. (2009) Mesenchymal stem cells: flip side of the coin. Cancer Res. 69(4):1255-8. Cole PD, Drachtman RA, Masterson M, Smith AK, Glod J, Zebala JA, Lisi S, Drapala DA, and Kamen BA. (2008) Phase 2B trial of Aminopterin in multiagent therapy for children with newly diagnosed Acute Lymphoblastic Leukemia. Cancer Chemotherapy and Pharmacology. 62:65-75. Mishra PJ, Mishra PJ, Humeniuk R, Medina, D, Alexe G, Mesirov JP, Ganesan S, Glod J, and Banerjee D. (2008) Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Research. 68:4331-39. Wollack, JB, Makori, B, Ahlawat, S, Koneru, R, Picinich, S, Smith, A, Goldman,ID, Qiu, A, Cole, PD, Glod, J and Kamen, B. (2008) Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. J. Neurochem. 104:1494. Menon LG, Picinich S, Koneru S, Gao H, Lin SY, Koneru M, Mayer-Kuckuk P, Glod J, and Banerjee D (2007) Differential gene expression associated with migration of Mesenchymal Stem Cells to conditioned medium From tumor cells or bone marrow cells. Stem Cells. 25:520. Menon LG, Picinich S, Koneru S, Gao H, Lin SY, Koneru M, Mayer-Kuckuk P, Glod J, and Banerjee D (2007) Differential gene expression associated with migration of Mesenchymal Stem Cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells. 25:520-28. Glod, J, Kobiler D, Noel M, Koneru R, Lehrer S, Medina D, Maric D, and Fine HA (2006) Monocytes form a vascular barrier and participate in vessel repair after brain injury Blood. 107:940-46. Glod, J., Kobiler, D., Noel, M., Maric, D., and Fine, H.A. (2006) Monocytes adopt a Brain Microvascular Endothelial Phenotype and Particpate in Vascular Repair after Brain Injury. Blood. 107(3):940-46. Anderson, SA, Glod, J, Arbab, AS, Noel, M, Ashari, P, Fine, HA, and Frank, JA. (2005) Non-invasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood. 105:420-5. Ferrari, N, Glod, J., Lee, J., Kobiler, D., and Fine H.A. (2003) Bone marrow-derived, endothelial progenitor-like cells as angiogenesis-Selective gene targeting vectors. Gene Therapy. 10:647-56. |
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