James S. Goydos
Associate Professor

Melanoma and soft tissue oncology

The goals of this project are to examine the relationship of known prognositic variables in primary melanomas and level of Grm1 expression, to perform in vivo testing of anti-glutamate therapies in melanoma xenograft models, and to determine if suppression of Grm1 signaling affects migration and invasion, uPA expression, and vasculogenic mimicry in aggressive melanoma cell lines.

Selected Publications

Shin SS, Wall BA, Goydos JS, Chen S. (2009) AKT2 is a downstream target of metabotropic glutamate receptor 1 (mGlu1). Pigment Cell Melanoma Res. Oct 20. [Epub ahead of print]

Yip D, Le MN, Chan JL, Lee JH, Mehnert JA, Yudd A, Kempf J, Shih WJ, Chen S, Goydos JS. (2009) A phase 0 trial of Riluzole in patients with resectable stage III and IV melanoma. Clin Cancer Res. 15(11):3896-902.

Solit DB, Osman I, Polsky D, Panageas KS, Daud A, Goydos JS, Teitcher J, Wolchok JD, Germino FJ, Krown SE, Coit D, Rosen N, Chapman PB. (2008) Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma. Clin Cancer Res. 14(24):8302-7.

Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. (2008) The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by
HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A. 105(43):16713-8.

Federico AC, Chagpar AB, Ross MI, Martin RC, Noyes RD, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Sussman JJ, McMasters KM, Scoggins CR. (2008) Sunbelt Melanoma Trial. Effect of multiple-nodal basin drainage on cutaneous melanoma. Arch Surg. 143(7):632-7; discussion 637-8.

Namkoong J, Shin S-S, Lee HJ, Marin YE, Wall BA, Goydos JS, Chen S. (2007) Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma, Cancer Research 67 (5): 2298-2305.

Lopez-Bergami P, Huang C, Goydos JS, Yip, D, Bar-Eli M, Herlyn M, Smalley KSM, Mahale A, Aaronson S, and Ronai Z. (2007) Re-wired ERK-JNK signaling pathways in melanoma. Cancer Cell 11(5):447-60.

Chagpar RB, Ross MI, Reintgen DS, Edwards MJ, Scoggins CR, Martin RC 2nd, Noyes RD, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Davidson BS, Sussman JJ, McMasters KM. (2007) Factors associated with improved survival among young adult melanoma patients despite a greater incidence of sentinel lymph node metastasis. J Surg Res 143(1): 164-168.

Scoggins CR, Ross MI, Reintgen DS, Noyes RD, Goydos JS, Beitsch PD, Urist MM, Ariyan,S, Sussman JJ, Edwards MJ, Chagpar AB, Martin RC, Stromberg AJ, Hagendoorn L, McMasters, KM (2006) Gender-related differences in outcome for melanoma patients. Ann Surgery, Volume 243(5), May pp 693-700.

Scoggins CR, Ross MI, Reintgen DS, Noyes RD, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Davidson BS, Sussman JJ, Edwards MJ, Martin RCG, Lewis AM, Stromberg AJ, Conrad AJ, Hagendoorn L, Albrecht J, McMasters KM. (2006) Prospective Multi-Institutional Study of Reverse Transcriptase Polymerase Chain Reaction for Molecular Staging of Melanoma. Journal of Clinical Oncology, Vol 24, No 18:2849-2857.

Goydos JS, Mann B, Kim H, Gabriel M, Shih W, Germino FJ, Gorski DH. (2005) Detection of B-RAF and N-RAS mutations in human melanoma. J Am Coll Surg. 200(3):362-70.

Kounalakis N, Goydos JS. (2005) Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management. Curr Oncol Rep. 7(5):377-82.

Kita T, Goydos J, Reitman E, Ravatn R, Lin Y, Shih WC, Kikuchi Y, Chin KV. (2004) Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma. Cancer Lett. 208(2):187-91

McMasters KM, Noyes RD, Reintgen DS, Goydos JS, Beitsch PD, Davidson BS, Sussman JJ, Gershenwald JE, Ross MI (2004) Sunbelt Melanoma Trial. Lessons learned from the Sunbelt Melanoma Trial. J Surg Oncol. 86(4):212-23.

Pollock PM, Cohen-Solal K, Sood R, Namkoong J, Martino JJ, Koganti A, Zhu H, Robbins C, Makalowska I, Shin SS, Marin Y, Roberts KG, Yudt LM, Chen A, Cheng J, Incao A, Pinkett HW, Graham CL, Dunn K, Crespo-Carbone SM, Mackason KR, Ryan KB, Sinsimer D, Goydos J, Reuhl KR, Eckhaus M, Meltzer PS, Pavan WJ, Trent JM, Chen S. (2003) Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nature Genetics 34(1):108-12.

Gorski GH, Leal AD, Goydos JS. (2003) Differential expression of vascular endothelial growth factor (VEGF) isoforms at different stages of melanoma progression. J Am Coll Surg. 197(3):408-18.

Goydos JS, and Gorski GH. (2003) Level of expression of vascular endothelial growth factor C (VEGF-C) correlates with stage of local/regional progression in patients with melanoma. Clin Cancer Res. 9(16 Pt 1):5962-7.

Alsina J, Gorsk DH, Germino FJ, Shih W, Lu SE, Zhang ZG, Yang JM, Hait WN, Goydos JS. (2003) Detection of mutations in the Mitogen-activated protein kinase (MAPK) pathway in human melanoma. Clin Cancer Res. 9(17):6419-25.