Karl Herrup
Professor II and Department Chair

Neurogenetics, cell cycle, cell death, CNS development, cerebellum, Autism, Alzheimer's disease

The focus of the Herrup lab is on cell cycle regulation in the adult neuron.  While most textbooks describe the typical CNS neuron as “permanently postmitotic,” we have been exploring the ways in which the textbook needs to be re-written.  We are particularly interested in the ways in which cell cycle dysregulation is linked to cell death – in normal situations and in human diseases such as Alzheimer’s disease.  Our work involves mouse genetics and animal models of human diseases, as well as direct work with human tissue.  Our technical approaches involve mammalian genetics and molecular biology.  Our assays are predominantly visual, relying heavily on histological and cytological analysis of neurons in brain sections and in culture.

View Dr. Herrup's publications in Pub Med