|
|
|
 |
Computational GeneticsMy area of research is purely computational in nature. I do not perform any work in a wet lab. To carry out my research projects. I develop new analytical methods. write computer programs to implement these methods. run computer programs written by both myself and others. and develop and maintain web sites for dissemination of results. My time is divided between basic research and developing tools and resources for use by the research community. My work focuses on developing and applying tools for genome mapping. On a level above DNA sequence. there exist several types of maps. including cytogenetic. linkage or meiotic. radiation hybrid (RH). and clone-based physical maps. One of my areas of research focuses on automating the construction of linkage and RH maps. The process of ordering markers on these two types of maps relies on statistical and heuristical methods. follows a stepwise algorithm. and is quite computationally intensive for large marker sets. I have written a computer program that is used for automated large-scale linkage and radiation hybrid mapping. MULTIMAP is freely available to the genetics community and has been used in several genome-wide mapping projects in humans and other organisms (mouse. rat. dog). The ability to rapidly and efficiently generate RH maps has facilitated my work on research projects examining the properties of different hybrid panels currently in use for mapping and the properties of the resultant maps.
In addition to building stand-alone maps. I also focus on map integration. These
different types of maps are typically each created and displayed as separate
entities. Links are made between markers in common between multiple types of
maps. but little effort has been made to define We are now embarking on a brand new area of research. to search for genes involved in female reproductive genetics - in other words. looking for genes that play a role in fertility. Additional information about my research can be found on my webpage at compgen.rutgers.edu. Selected PublicationsBuyske S. Bates ME. Gharani N. Matise TC. Tischfield JA. Manowitz P. (2006) Cognitive traits link to human chromosomal regions. Behav Genet. 36(1):65-76. Kim DD. Kim TT. Walsh T. Kobayashi Y. Matise TC. Buyske S. Gabriel A. (2004) Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res. 14(9):1719-25. Majewski J. Schultz DW. Weleber RG. Schain MB. Edwards AO. Matise TC. Acott TS. Ott J. Klein ML. (2003) Age-related macular degeneration--a genome scan in extended families. American Journal of Human Genetics. 73(3):540-50. Clark AG. Nielsen R. Signorovitch J. Matise TC. Glanowski S. Heil J. Winn-Deen ES. Holden AL. Lai E. (2003) Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome. American Journal of Human Genetics. 73(2):285-300. Matise TC. Sachidanandam R. Clark AG. Kruglyak L. Wijsman E. Kakol J. Buyske S. Chui B. Cohen P. de Toma C. Ehm M. Glanowski S. He C. Heil J. Markianos K. McMullen I. Pericak-Vance MA. Silbergleit A. Stein L. Wagner M. Wilson AF. Winick JD. Winn-Deen ES. Yamashiro CT. Cann HM. Lai E. Holden AL. (2003) A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. American Journal of Human Genetics. 73(2):271-84. DeWan AT. Parrado AR. Matise TC. Leal SM. (2002) Map error reduction: using genetic and sequence-based physical maps to order closely linked markers. Human Heredity. 54(1):34-44. Matise TC. Porter CJ. Buyske S. Cuttichia AJ. Sulman EP. White PS. (2002) Systematic evaluation of map quality: human chromosome 22. American Journal of Human Genetics. 70(6):1398-410. DeWan AT. Parrado AR. Matise TC. Leal SM. (2002) The map problem: a comparison of genetic and sequence-based physical maps. American Journal of Human Genetics. 70(1):101-7. |
|
