Kenneth H. McKeever Associate Professor Rutgers University Dept. Animal Sciences Bartlett Hall School of Env & Biol Sciences New Brunswick. NJ 08903 (732) 932-9390 FAX - 6996 mckeever@aesop.rutgers.edu

Comparative exercise and cardiovascular physiology

On a basic level. my research has focused on comparative exercise and cardiovascular physiology with a particular interest in baroreceptor function and renal and neuroendocrine control of blood pressure. blood volume. and fluid and electrolyte balance. On an applied level. my research has focused on the effects of ergogenic (performance-enhancing) practices on the physiological responses of the equine athlete. Research in the lab is focused on basic physiology of the equine athlete . Our mission is not to cure sick horses. but rather to enhance our understanding of the equine athlete and the physiology of prevent problems before they occur. There are many similarities between horses and humans and we are also using the horse as a model to study the effects of aging on a variety of physiological systems. Ultimately our goal is to provide information for horse owners around the world and to find new ways to make happier. healthier. horses.

Selected Publications

Kearns CF, McKeever KH. (2008) Clenbuterol and the horse revisited. Vet J. 182(3):384-91.

Manso Filho HC, Costa HE, Wu G, McKeever KH, Watford M. (2008) Equine placenta expresses glutamine synthetase. Vet Res Commun. 33(2):175-82.

Manso Filho HC, Costa HE, Wang Y, McKeever KH, Watford M. (2008) Distribution of glutamine synthetase and an inverse relationship between glutamine synthetase expression and intramuscular glutamine concentration in the horse. Comp Biochem Physiol B Biochem Mol Biol. 150(3):326-30.

Manso Filho HC, McKeever KH, Gordon ME, Costa HE, Watford M. (2007) Novel findings regarding Glut-4 expression in adipose tissue and muscle in horses--a preliminary report. Vet J. 174(3):565-9.

Kearns CF. McKeever KH. Malinowski K. (2006) Changes in adipopnectin. leptin. and fat mass after clenbuterol treatment in horses. Med Sci Sports Exerc. 38(2):262-7.

Gordon ME. McKeever KH. Betros CL. Manso Filho HC. (2006) Exercise-induced alterations in plasma concentrations of ghrelin. adiponectin. leptin. glucose. insulin. and cortisol in horses. Vet J. 173(3):532-40.

Gordon ME. McKeever KH. Betros CL. Manso Filho HC. (2005) Plasma leptin. ghrelin and adiponectin concentrations in young fit racehorses versus mature unfit standardbreds. Vet J. 173(1):91-100.

Kearns CF. McKeever KH. Roegner V. Brady SM. Malinowski K. (2005) Adiponectin and leptin are related to fat mass in horses. Vet J. 172(3):460-5.

McKeever. K.H (2004). Physiology of body fluids in the equine athlete. Equine Sports Medicine and Surgery:Basic and Clinical Sciences of the Equine Athlete Eds: K. Hinchcliff. A. Kaneps. R. Geor. Elsevier. Philadelphia. Chpt. 38. p. 853-871.

McKeever. K. & Gordon. M. (2004) Endocrine alterations in the equine athlete. Equine Sports Medicine and Surgery: Basic and Clinical Sciences of the Equine Athlete Eds: K. Hinchcliff. A. Kaneps. R. Geor. Elsevier. Philadelphia. Chpt. 35. pp. 793-814.

Malinowski. K. Kearns. C.F.. Guirnalda. P.D.. Roegner. V. and McKeever. K.H. (2004). Effect of chronic clenbuterol administration on immune function in horses. J Animal Sci. 82: 3500-3507.

Abe. T. Kearns. C.F.. Manso Filho. H.C.. Sato. Y.. Sleeper. M.. McKeever. K.H. (2004). Moderate vascular occlusion produced acute increases in skeletal muscle size and clinical blood parameters in Standardbred horses. Equine and Comparative Exercise Physiology 1:239-243.

Lehnhard. R.A.. McKeever. K.H.. Kearns. C. F. and Beekley. M. D. (2004). Aging- related changes in fat free mass and myosin heavy chain in Standardbred mares. The Veterinary Journal 167: 59-66.

McKeever. K.H (2003). Aging and how it affects the physiological response to exercise in the horse. Clinical techniques in equine practice - sports medicine/exercise physiology series 2 (3): 258-265.

McKeever. K.H. (2003). Overtraining Syndrome In Standardbred Horses: New Insight into the Role of Red Blood Cell Hypervolemia The Veterinary Journal 165:190-192.

Plant. D.R.. Kearns. C.F.. McKeever. K.H.. Lynch. G.S. (2003). Short-term clenbuterol treatment does not affect Ca2+-sensitivity of fast skeletal muscle fibers from horses. Journal of Muscle Research and Cell Motility 24:471-476.

Beekley. M.D.. Ideus. J.M.. Brechue. W.F.. Kearns. C.F.. McKeever. K.H. (2003). Chronic clenbuterol administration alters myosin heavy chain composition in Standardbred mares. The Veterinary Journal 165: 234-239.