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Joseph Naus
Professor
Rutgers University
Department of Statistics
Hill Center - Busch Campus
Rutgers University
Piscataway. NJ 08854
(732) 445-2695
FAX - 3428
naus@stat.rutgers.edu |
Applied probability. sampling theory. data quality control. clustering and coincidence models. matching
in DNA sequences
In studying DNA sequences. molecular biologists sometimes
search for fragments of two sequences that when aligned match at most of
the positions. The scientists seek to determine what is an unusually long
match. One problem area we work on is where the two long sequences are aligned
by an overall criterion. and then the scientists highlight matching (perfectly
or almost) subsequences with common location in the two sequences.
A second problem area we are working on is where the two long sequences
are compared under all alignments. and searched for unusual almost matching
fragments. For various models and scoring we seek to determine the statistical
significance of such "matches".
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