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Wilma K. Olson
Professor
Rutgers University
Department of Chemistry
Wright-Rieman Labs. Busch Campus
Piscataway. NJ 08854
(732) 445-3993
FAX - 5958
olson@rutchem.rutgers.edu |
Biopolymer conformation and properties
The primary research goal of our research group is
to understand the three-dimensional structure and the structure-dependent
properties of the nucleic acids in terms of their constituent chemical
architecture. Problems of current interest include: (1) new computational
methods to generate and analyze constrained configurations such as the loops and
hairpins of RNA. the cruciform junctions of DNA. and the closed. superhelical
arrangements of the double helix; (2) computer simulation of the DNA helix to
random coil transition; (3) improved procedures to analyze local structural
morphology and to model the effects of base sequence and electrostatics on
macromolecular flexibility; (4) new computational models of protein-nucleic acid
interactions.
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