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CNS injury mechanics, tissue engineering, nerve and spinal cord regeneration, acupuncture, microfluidicsWe are interested in understanding Central Nervous System injury, repair, and regeneration. We study the tissue and cellular biomechanics associated with traumatic injury using in vivo, in situ, and computational models. We attempt to dictate cell migration and axon regeneration by imposing spatial patterns of mechanical properties and bioactivity in collagen gels using BioMEMS. Finally, we use in vitro and computational models to investigate mechanotransduction as a mechanism underlying the response to acupuncture. Selected PublicationsMonteiro GA, Fernandes AV, Sundararaghavan HG, Shreiber DI. (2009) Positively and negatively modulating cell adhesion to type I collagen via peptide grafting. Tissue Eng Part A. Jan 28. [Epub ahead of print] Lin DC, Shreiber DI, Dimitriadis EK, Horkay F. (2008) Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models. Biomech Model Mechanobiol. Nov 2. [Epub ahead of print] Sundararaghavan HG, Monteiro GA, Firestein BL, Shreiber DI. (2008) Neurite growth in 3D collagen gels with gradients of mechanical properties. Biotechnol Bioeng. 102(2):632-43. Shreiber DI, Hao H, Elias RA. (2008) Probing the influence of myelin and glia on the tensile properties of the spinal cord. Biomech Model Mechanobiol. Aug 23. [Epub ahead of print] Maikos JT, Qian Z, Metaxas D, Shreiber DI. (2008) Finite element analysis of spinal cord injury in the rat. J Neurotrauma. 25(7):795-816. Julias M, Edgar LT, Buettner HM, Shreiber DI. (2008) An in vitro assay of collagen fiber alignment by acupuncture needle rotation. Biomed Eng Online. 7:19. Sharma RI, Shreiber DI, Moghe PV. (2008) Nanoscale variation of bioadhesive substrates as a tool for engineering of cell matrix assembly. Tissue Eng Part A. 14(7):1237-50. Maikos JT, Elias RA, Shreiber DI. (2008) Mechanical properties of dura mater from the rat brain and spinal cord. J Neurotrauma. 25(1):38-51. Hao H, Shreiber DI. (2007) Axon kinematics change during growth and development. J Biomech Eng. 129(4):511-22. Maikos JT, Shreiber DI. (2007) Immediate damage to the blood-spinal cord barrier due to mechanical trauma. J Neurotrauma. 24(3):492-507. |
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