 | Noah Weisleder
Assistant Professor
UMDNJ-RWJMS
Dept. of Physiology/Biophysics
RWJMS Research Building Room 162
683 Hoes Lane
Piscataway. NJ 08854
(732) 235-4782
FAX - 4483
weisleno@umdnj.edu |
Alteration to Ca2+ handling in muscle during aging
Our
studies center on analysis the molecular machinery that mediates
excitation-contraction coupling during physiological and pathophysiological
states. Recent publications have established that altered Ca2+ spark
signaling is observed in skeletal muscle fibers from aged and dystrophic
muscle fibers. These Ca2+ sparks are regulated by lipid signaling cascades
and may play a role in modulating Ca2+ entry into muscle cells. Perturbation
of the capacity of muscle cells to control Ca2+ entry has been linked to the
pathology observed in muscular dystrophy. Additionally, alteration of the
cellular membrane repair and remodeling mechanisms is thought to contribute
to the progression of muscular dystrophy. Study of these related mechanisms
and the disruption of such processes in disease states and aging muscle
should lead to potential therapeutic approaches for muscle disorders that
involve aberrant Ca2+ handling.
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