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Guofeng You
Professor
Rutgers University
Department of Pharmaceutics
Ernest Mario School of Pharmacy
William Levine Hall
Piscataway. NJ 08854
(732) 445-3831, Ext 218
FAX - 3134
gyou@rci.rutgers.edu |
Molecular and cellular pharmacology. drug/toxin
elimination. transporter
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The long term goal of Dr. You's research is to elucidate the molecular and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Currently, her research focuses on 1) the structure and function relationships of these transporters, and 2) their short-term and long-term regulatory mechanisms. Techniques in molecular biology, biochemistry, and biophysics are used to analyze the transport mechanisms. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
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